The Generative Genomics Engine

Predict the results of future or even impossible gene expression experiments with our generative AI models.

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For Scientists by Scientists

CLINICAL DECISION SUPPORT

AI-enriched metadata and expression profiles support biomarker-driven clinical trial design and real-world evidence generation

CLINICAL BIOMARKER DISCOVERY

AI-generated gene expression data accelerates identification of predictive biomarkers for patient stratification, drug response, and clinical trial design across therapeutic areas

CLINICAL TRIAL OPTIMIZATION

AI-generated datasets help identify patient populations most likely to respond to investigational therapies, reducing trial failure rates and development timelines

PRECISION MEDICINE INSIGHTS

Harmonized expression data across diseases, tissues, and perturbations supports development of companion diagnostics and personalized treatment strategies

PHARMACODYNAMIC MODELING

Synthetic RNA-seq data supports mechanism of action studies, dose-response modeling, and target engagement analysis for clinical engagement

Accelerate insight extraction from large-scale omics

Accelerate insight extraction from large-scale omics

Leverage model embeddings for disease signature development, biomarker discovery, and cell type annotation

De-risk early discovery and ID high-confidence targets

De-risk early discovery and ID high-confidence targets

Our foundation models integrate your proprietary multi-omics data with a vast universe of public biological knowledge. This creates a unified, queryable map of cellular biology, enabling your teams to identify novel targets, validate mechanisms of action (MoA), and discover predictive biomarkers.

Predict therapeutic response and mechanisms in silico

Predict therapeutic response and mechanisms in silico

Our models simulate how cells will respond to novel perturbations, including your drug candidates. Forecast downstream effects, identify potential off-target liabilities, and elucidate complex MoA before committing to clinical trials.

Optimize clinical trial design and enable precision medicine

Optimize clinical trial design and enable precision medicine

Our platform helps you enrich for patient subgroups, de-risk your clinical programs, increase the probability of success, and lay the groundwork for developing companion diagnostics.

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Synthesize Bio enables teams to explore broader research spaces and make faster, more confident drug development decisions. We are actively engaging with biopharma partners to deploy these capabilities at scale. Message us at partnerships@synthesize.bio.
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